• A word on the lab

    Our unit is composed of researchers specialized in different cognitive domains in human, and researchers working on animal. We put together our different expertises to build a more integrated model of schizophrenia, a complex and multiform pathology. Our common objective is to understand the pathophysiology of schizophrenia and to search for new therapeutic targets. Anne Giersch, Director

We aim at understanding the pathophysiology of schizophrenia , and at developing new therapeutic concepts.

The diagnosis of schizophrenia relies on clinical symptoms exclusively, even though the pathology is associated to invalidating cognitive disorders, on which antipsychotic drugs have no effect. We identified two series of cognitive disorders which might characterize schizophrenia: the disorders of autobiographical memory, which affect the sense of elf, and more elementary cognitive disorders leading to a disruption in the sense of time continuity. We explore the pathophysiological role of these disorders by exploring their link with symptoms like delusions. We also study the link between cognitive disorders and neuronal network alterations, by means of imaging methods in human (fMRI, EEG), and animal models (ketamine injection, neurodevelopmental models). Our work leads to two types of therapeutic concept. On the one hand, we develop methods of cognitive remediation, by targeting especially identity disorders. On the other hand, we try to reproduce more elementary cognitive disorders in our animal models, in order to check, in the longer term, if deep brain stimulation can correct them. 

Team

Cliquez sur les photos pour accéder au thèmes de recherche de chaque personne.


Anne
Giersch

 

 

 

 

 

 

 

 

Alain
Louilot


Anne
Bonnefond

 

 

 

 

 

 

 

Didier
Pinault


Fabrice
Berna


Gilles
Bertschy

 

 

 

 

 

 

 

Jean-Marie
Danion

 

 

 

 

 

Brigitte Kieffer

 

 

 

 

 

Laurence
Lalanne

Isabelle
Offerlin-Meyer

   

Raymund Schwan

Sébastien WEIBEL Pierre
Vidailhet

Matthieu Chidharom, Julien Krieg, Eduardo Marques-Carneiro, Bich-Thuy Pham, Anne Bonnefond (2021), Investigation of electrophysiological precursors of attentional errors in schizophrenia: Toward a better understanding of abnormal proactive control engagement, Journal of Psychiatric Research. https://doi.org/10.1016/j.jpsychires.2021.05.079

vendredi 3 mars à 11h en salle polyvalente : 'Un réseau amydgale-striatum et la flexibilité de l'attente temporelle' : séminaire présenté par Valérie Doyère  invitée par Anne Giersch.

vendredi 10 mars en salle polyvalente :

                    10h30 Automated analysis of semantic features in verbal fluency tasks: the case of bipolar disorder (Guilherme Frederico Lima, Department of                             Mathematics, University of Cambridge, UK, invité par Luisa Weiner)

                    11h Analysis of prosodic speech features in bipolar disorder (Nicola Vanello et Andrea Guidi, Department of Information Engineering,  University of                     Pisa, Italy, invités par Gilles Bertschy)

vendredi 17 mars à 11h en salle polyvalente : Martin Desseilles  est Professeur de psychopathologie à l’Université de Namur et sa conférence portera  sur « Bipolarité et créativité » avec un après-midi de discussion des résultats.   (invité par Gilles Bertschy)

28-29 mars  2017 : Neurex workshop organisé par Laurence Lalanne  :   “Addiction: a neurobiological and cognitive brain disorder”

 

 

 

 

Thomas Schwitzer received the Best Publication of the Year Award in Psychiatry for his publication in JAMA Ophthalmology entitled Association Between Regular Cannabis Use and Ganglion Cell Dysfunction

January 2017

Brice Martin received the Psychiatry's Institute for his communication : 
"Conscience de soi dans la psychose »

Our research unit regularly hosts postgraduate students (L, M1, M2), PhD students and postdoctoral researchers. Thank you to contact the principal investigators for any application.

  • We seek

    PostDoctoral Fellowship

    Applications are invited for a postdoctoral position in the context of a multisite, multipartner collaboration between Anne Giersch (INSERM U1114, Strasbourg Univ.), Céline Meillier, Jack Foucher & Sylvain Faisan (I-Cube, CNRS, Strasbourg Univ.) and Virginie van Wassenhove (NeuroSpin, Saclay) as part of the FRM project entitled “Time, self and resting states in schizophrenia and bipolar disorder”.

     

    The position is for around 16 months, salary will be commensurate with experience and start date is ASAP.

     

    Profile: The successful candidate will have demonstrated proficiency with data processing and/or data analysis.

                                                            

    Duties: The successful candidate will be responsible for the analysis of fMRI activity and the impact of time tasks on the dynamic of resting states networks. Moreover, the successful candidate will also examine the changes in the network activation over time, and how this dynamic and its disturbance in patients with schizophrenia and depression are governed by the networks identified during the time tasks.

     

    Additional responsibilities include:

    • Literature review and mastery of the topic;
    • Quality controls for the analysis of fMRI data;
    • Effective communication with peers within the consortium; 
    • Concise progress reports and coordination of discussion meetings among partners;
    • Analysis and publication of the data;

    Eligible qualifications for this position include:

    • PhD in cognitive neuroscience / or PhD in Neuroscience (topic cognition or psychiatry); but associated with a solid background in signal processing
    • Expertise in statistics;
    • Strong coding aptitudes, proficiency in Python, Matlab or C++;
    • Excellent written and verbal communication skills in English;
    • Strong interpersonal skills, assertive and proactive;

    The successful participant will be located at the University of Strasbourg in the INSERM Unit 1114, and will work under the supervision of; he will benefit from the consortium and work in collaboration with Céline Meillier and Sylvain Faisan (ICube) and Virginie van Wassenhove (NeuroSpin).

    The University of Strasbourg is one of the largest scientific hub in France, with close partnership in Europe, and especially cross-boarder exchanges with Germany and Switzerland. I-Cube (CNRS) is a large laboratory with more than 650 members working in the fields of engineering science and computer science, with imaging as the unifying theme. The INSERM laboratory headed by Anne Giersch works in close collaboration with both i-Cube and Virginie van Wassenhove since years. Her laboratory is recognized for its expertise in the field of cognition and psychotic disorders.

    Please, submit a letter detailing your current research interests, a curriculum vitae, and the contact information of up to three individuals who can provide a letter of recommendation to Anne Giersch (giersch@unistra.fr).

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